Patients with First Degree Relatives with Disease Quick Table: All Relevant Recommendations
Please note: In 2003, the CTF updated its Grades of Recommendations to include an "I Recommendation" for situations where insufficient evidence exists to allow a recommendation to be made. (Formerly, these situations were captured under a "C Recommendation".) This change is not retroactive, and all "C Recommendations" made prior to 2003 have not been reevaluated in light of the new "I" recommendation grade. For a discussion of these recommendation grades, please link to the 2003 article in the Canadian Medical Association Journal here.
Quick Table of All Recommendations Specific and Relevant to Patients with First Degree Relatives with Disease
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| "B" Recommendations | ||
| Colorectal cancer | Flexible sigmoidoscopy beginning at puberty, genetic testing | High-risk adults with FAP |
| Colorectal cancer | Colonoscopy | High-risk adults with HNPCC |
| Cystic fibrosis | DNA analysis for carrier status | Siblings of children with CF |
| Cystic fibrosis | Sweat test, immunoreactive trypsin and "BM meconium" test | Siblings of children with CF |
| Hemoglobinopathies | DNA analysis, fetal tissue sample/counselling | Families, parents confirmed carriers |
| Skin cancer | Physical exam, skin | First degree relative with melanoma |
| "C" Recommendations | ||
| Colorectal cancer | Colonoscopy | Average risk adults, high-risk adults with family history of polyps/CRC |
| Ovarian cancer | Pelvic exam, transvaginal ultrasound, CA 125 or combination | Family history 1st degree relative |
| Tobacco-caused disease | Counselling on environmental tobacco smoke | Families with smokers |
| "D" Recommendations | ||
| Developmental hip dysplasia | Selective screening | Infants with family history of DDH |