Postmenopausal Hormone Replacement Therapy for Primary Prevention of Cardiovascular and Cerebrovascular Disease
Prepared by B. L. Abramson, with the Canadian Task Force on Preventive Health Care
These recommendations were finalized by the Task Force in February 2003.
Mosca
L, Manson JE, Sutherland SE, Langer RD, Manolio T, Barrett-Connor E.
Cardiovascular disease in women. A statement for healthcare professionals
from the American Heart Association. Circulation 1997;96:2468-82.
Eaker
ED, Chesebro JH, Sacks FM, Wenger NK, Whisnant JP, Winston M. Cardiovascular
disease in women. Circulation 1993;88:1999-2009.
Nault
F, Wilkins K. Deaths 1993. Health Rep 1995;7:51-60.
Heart
and Stroke Foundation of Canada. Heart disease and stroke in Canada 1995.
Ottawa: The Foundation; 1995.
Gotto
AMJ. Lipid lowering, regression, and coronary events: a review of the
interdisciplinary council on lipids and cardiovascular risk intervention,
seventh council meeting [special report]. Circulation 1995;92:646-56.
Hulley
S, Grady D, Bush TL, Furberg CD, Herrington DM, Riggs B, Vittinghoff E.
Randomized trial of estrogen plus progestin for secondary prevention of
coronary heart disease in postmenopausal women. JAMA 1998;280:605-13.
Herrington
DM, Reboussin DM, Brosnihan KB, et al. Effects of estrogen replacement on
the progression of coronary-artery atherosclerosis. N Engl J Med
2000;343:522-29.
Grodstein
F, Manson JE, Stampfer MJ. Postmenopausal hormone use and secondary
prevention of coronary events in the nurses' health study. a prospective,
observational study. Ann Intern Med 2001;135(1):1-8.
Grady
D, Herrington D, Bittner V, et al for the HERS Research Group.
Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart
and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA
2002;288:49-57.
Rossouw
JE, Finnegan LP, Harlan WR, Pinn VW, Clifford C, McGowan JA. The evolution
of the Women's Health Initiative: perspectives from the NIH.
J Am Med Womens Assoc
1995;50:50-5.
Writing Group for
the Women’s Health Initiative Investigators. Risks and benefits of
estrogen plus progestin in healthy postmenopausal women: Principal results
from the Women’s Health Initiative randomized controlled trial. JAMA
2002:288:321-37.
Woolf
SH, Battista RN, Anderson GM, Logan AG, Wang E, Canadian Task Force on the
Periodic Health Examination. Assessing the clinical effectiveness of
preventive manouvres: analytic principles and systematic methods in
reviewing evidnece and developing clincal practice recommendations. J Clin
Epidemiol 1990;43:891-905.
Grady
D, Rubin SM, Petitti DB, Fox CS, Black D, Ettinger B, Ernster VL, Cummings
SR. Hormone therapy to prevent disease and prolong life in postmenopausal
women. Ann Intern Med 1992;117:1016-37.
Bush
TL. Noncontraceptive estrogen use and risk of cardiovascular disease: an
overview and critique of the literature. In Korenman SG, editor. The
Menopause. Biological and clinical consequences of ovarian failure:
evolution and management. Norwell, MA: Sereno Symposia; 1990. p. 211-23.
Stampfer
MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a
quantitative assessment of the epidemiologic evidence. Prev Med
1991;20:47-63.
Cauley
JA, Seeley DG, Browner WS, Ensrud K, Kuller LH, Lipschutz RC, et al.
Estrogen replacement therapy and mortality among older women. Arch Intern
Med 1997;157:2181-7.
Falkeborn
M, Persson I, Adami H, Bergstrom R, Eaker E, Lithell H, et al. The risk of
acute myocardial infarction after oestrogen and oestrogen-progestogen
replacement. Br J Obstet Gynaecol 1992;99:821-8.
Falkeborn
M, Persson I, Terent A, Adami H, Lithell H, Bergstrom R. Hormone replacement
therapy and the risk of stroke. Arch Intern Med 1993;153:1201-9.
Finucane
FF, Madans JH, Bush TL, Wolf PH, Kleinman JC. Decreased risk of stroke among
postmenopausal hormone users. Arch Intern Med 1993;135:73-9.
Folsom
AR, Mink PJ, Sellers TA, Hong C, Zheng W, Potter JD. Hormonal replacement
therapy and morbidity and mortality in a prospective study of posmenopausal
women. Am J Public Health 1995;85:1128-32.
Grodstein
F, Stampfer MJ, Colditz GA, Willett WC, Manson JE, Joffe M, et al.
Postmenopausal hormone therapy and mortality. N Engl J Med 1997;336:1769-75.
Lafferty
FW, Fiske ME. Postmenopausal estrogen replacement: a long-term cohort study.
Am J Med 1994;97:66-77.
Schairer
C, Adami H, Hoover R, Persson I. Cause-specific mortality in women receiving
hormone replacement therapy. Epidemiology 1997;8:59-65.
Sourander
L, Rajala T, Raiha I, Makinen J, Erkkola R, Helenius H. Cardiovascular and
cancer morbidity and mortality and sudden cardiac death in postmenopausal
women on oestrogen replacement therapy (ERY). Lancet 1998;352:1965-9.
Sturgeon
SR, Schairer C, Brinton LA, Pearson T, Hoover RN. Evidence of a healthy
estrogen user survivor effect. Epidemiology 1995;6:227-31.
Avila
MH, Walker AM, Jick H. Use of replacement estrogens and the risk of
myocardial infarction. Epidemiology 1990;1:128-33.
Bush
TL, Barrett-Connor E, Cowan LD, Criqui MH, Wallace RB, Suchindran CM, et al.
Cardiovascular mortality and noncontraceptive use of estrogen in
women: results from the Lipid Research Clinics Program Follow-up Study.
Circulation 1987;75:1102-9.
Criqui
MH, Suarez L, Barrett-Connor E, McPhillips J, Wingard DL, Garland C.
Postmenopausal estrogen use and mortality. Am J Epidemiol 1988;128:606-14.
Grodstein
F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Rosner B, et al. Postmenopausal estogen and progestin use and the risk of
cardivascular disease. N Engl J Med 1996;335:453-61.
Henderson
BE, Paganini-Hill A, Ross RK. Decreased mortality in users of estrogen
replacement therapy. Arch Intern Med 1991;151:75-8.
Nachtigall
LE, Nachtigall RH, Nachtigall RD, Beckman ME. Estrogen replacement therapy
II: a prospective study in relationship to carcinoma and cardiovascular and
metabolic problems. Obstet
Gynecol 1979;54:74-9.
Wilson
PW, Garrison RJ, Castelli WP. Postmenopausal estrogen use, cigarette
smoking, and cardiovascular morbidity in women over 50: The Framingham
Study. N Engl J Med 1985;313:1038-43.
Wolf
PH, Madans JH, Finucane FF, Higgins M, Kleinman JC. Reduction of
cardiovascular disease-related mortality amongpostmenopausal women who use
hormones: evidence from a national cohort. Am J Obstet Gynecol
1991;164:489-94.
Writing
Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens
on heart disease risk factors in postmenopausal women. The postmenopausal
estrogen/progestin interventions (PEPI) trial. JAMA 1995;273:199-208.
Adams
MR, Register TC, Golden DL, Wagner JD, Williams JK. Medoxyprogesterone
acetate antagonizes inhibitory effects of conjugated equine estrogens on
coronary artery atheroscerosis. Arterioscler Thromb Vasc Biol
1997;17:217-21.
Miller
VM, Vanhoutte PM. Progestrone and modulation of endothelium-dependent
responses in canine coronary arteries. Am J Physiol 1991;261:R1022-7.
Schroder
J, Doren M, Schneider B, Oettel M. Are the antioxidative effects of 17 beta-estradiol
modified by concomitant administration of a progestin? Maturitas
1996;25:133-9.
Eaker
ED, Castelli WP. Differential risk of coronary heart disease among women in
the Framingham Study. Proceedings of the workshop on coronary heart disease
in women. NIH Administrative Report. Bethesda, MD: National Institutes of
Health; 1987.
Miller J, Chan BK, Nelson HD. Postmenopausal
estrogen replacement and risk for venous thromboembolism: a systematic
review and meta-analysis for the U.S. Preventive Services Task Force. Ann
Intern Med 2002;136(9):680-90.
Cheung
AM, Feig DS, Kapral MK, Diaz-Granados N, Dodin S, with the Canadian Task
Force on Preventive Health Care. Prevention of osteoporosis and osteoporotic
fractures in postmenopausal women: systematic
review & recommendations. CTFPHC
Technical Report #02-2. October 2002. London, ON: Canadian Task Force.
Cheung
AM, Proctor WR, Stewart DE, with the Canadian Task Force on Preventive
Health Care. The effect of hormone
replacement therapy on cancer in postmenopausal women: systematic review. CTFPHC
Technical Report #02-4. November 2002. London, ON: Canadian Task Force.
Wathen
CN, Feig DS, Feightner JW, Abramson B, Cheung AM. Hormone replacement
therapy for the primary prevention of chronic disease: recommendation
statement by the Canadian Task Force on Preventive Health Care. Submitted to
Can Med Assoc J; March 2003.
U.S. Preventive Services Task Force.
Postmenopausal hormone replacement therapy for the primary prevention of
chronic conditions: recommendations and rationale. October 2002. Agency for
Healthcare Research and Quality, Rockville, MD.
Available from: URL http://www.ahrq.gov/clinic/3rduspstf/hrt/hrtrr.htm
Society
of Obstetricians and Gynaecologists of Canada. SOGC cautions women not to
overreact to US study [press release]. Ottawa: The Society; 2002.
Abramson
BL, Derzko C, Lalonde A, Reid R, Turek M, Wielgosz A. Hormone replacement
therapy and cardiovascular disease: a joint statement. Can J Cardiol 2002
Jul;18(7):723-4. See also an updated statement by these authors at www.ccs.ca/)
(accessed 2004 Mar 01).
American
College of Obstetricians and Gynecologists. Statement on the Estrogen plus
Progestin trial of the Women's Health Initiative. ACOG
News Release July 9, 2002. Available from: URL http://www.acog.org/from_home/publications/press_releases/nr07-09-02.cfm
North
American Menopausal Society. Amended Report from the NAMS Advisory Panel on
Postmenopausal Hormone Therapy. Menopause
2003;10(1):6-12.
Harris RP, Helfand M, Woolf SH, Lohr KN, Mulrow CD, Teutsch SM, et al. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med 2001;20(3 Suppl):21-35.